纳米药物-多功能聚合物药物递送系统研究-英文( 货号:756841364) azw3 极速 lit 地址 下载 rb pdf mobi

基本信息

商品名称： 纳米药物-多功能聚合物药物递送系统研究-英文

出版社： 江苏大学出版社

出版时间：2020-08-01

作者：张源源

译者：

开本： 32开

定价： 42.00

页数：150

印次： 1

ISBN号：9787568413640

商品类型：图书

版次： 1 内容提要

本书为全英文学术专著，主要介绍刺激响应聚合物和聚合物杂化纳米药物载体的设计、制备、表征和应用。全书包括四章，第一章主要介绍纳米药物传递体如何实现跨越生物学屏障，改善药物分布，实现治疗的靶向；第二章主要介绍中空介孔硅材料作为载体的三重刺激响应药物释放系统；第三章主要介绍以中空介孔硅为载体的光热－化学联合治疗材料；第四章描述了以两亲聚合物作为载体的叶酸靶向光热－化学联合治疗聚合物材料。

目录

Chapter 1 INTRODUCTION

1.1 Nanoparticles in Drug Delivery

1.1.1 Role of nanoparticles in drug delivery

1.1.2 Composition of drug delivery nanocarriers

1.1.3 FDA-approved therapeutic nanoagents

1.2 Design Rules for Targeted Drug Delivery Nanoplatform

1.2.1 Stimuli-responsive drug release

1.2.2 Biocompatibility and biodegradability

1.2.3 Stability, size and targeting

1.3 Photothermal Therapy

1.3.1 NIR induced photothermal therapy

1.3.2 NIR absorbing materials for photothermal therapy

1.3.3 Polymer for the delivery of NIR-absorbing dye

1.3.4 Combined photothermal-chemotherapy

Chapter 2 POLYMER-COATED HOLLOW MESOPO-ROUS SILICA NANOPARTICLES FOR TRIPLE-RESPONSIVE DRUG DELIVERY

2.1 Introduction

2.2 Materials and Methods

2.2.1 Preparation of o-nitrobenzyl linkage

2.2.2 Preparation of PDEAEMA coated HMSNs

2.2.3 Preparation of DOX-loaded nanoparticles

2.2.4 Drug release behavior

2.2.5 Cellular uptake study

2.2.6 Cytotoxicity study

2.3 Results and Discussiona

2.3.1 Preparation of HMSNs-PDEAEMA

2.3.2 Loading and triggered release of DOX

2.3.3 Cellular uptake and intracellular release

2.3.4 In vitro antimmor study

2.4 Conclusion

Chapter 3 POLYMERIC PRODRUG GRAFTED HOLLOW MESOPOROUS SILICA NANOPAR-TICLES ENCAPSULATING NIR-ABSOR BING

DYE FOR POTENT COMBINED PHOTOTHERMAL-CHEMOTHERAPY

3.1 Introduction

3.2 Materials and Methods

3.2.1 Synthesis of HMSNs-RAFT

3.2.2 HMSNs-DOX prodrug

3.2.3 Preparation of HMSNs-DOX/IP

3.2.4 Drug release, dye loading and photothermal effect

3.2.5 Cellular uptake study

3.2.6 In vitro cytotoxicity study

3.3 Results and Discussion

3.3.1 Synthesis and characterization of HMSNs-DOX

3.3.2 Drug release, dye loading and photothermal effects

3.3.3 Cellular uptake and intracellular release

3.3.4 In vitro antitumor study

3.4 Conclusion

Chapter 4 ACID-SENSITIVE POLYMERIC DOXORUBICIN PRODRUG MICELLES ENCAPSULATING NEAR-INFRARED DYE FOR

TARGETED COMBINED PHOTOTHERMAL-CHEMOTHERAPY

4.1 Introduction

4.2 Materials and Methods

4.2.1 Synthesis of block copolymer

4.2.2 Folic acid modification and deprotection

4.2.3 Synthesis of DOX prodrug

4.2.4 Formation of IR.825-1oaded PDOX micelles

4.2.5 In vitro drug release

4.2.6 Cellular uptake study

4.2.7 In vitro cytotoxicity study

4.2.8 In vivo antitumor efficacy studies

4.3 Results and Discussion

4.3.1 Synthesis and characterization

4.3.2 Self-assembly behavior

4.3.3 Drug release and photothermal effects

4.3.4 IntraceUular uptake

4.3.5 In vitro antitumor study

4.3.6 In vivo combinational therapeutic efficacy

4.4 Conclusion

Chapter 5 CONCLUSION AND OUTLOOK

REFERENCES

LIST OF ACRONYMS

EPILOGUE

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